Nephron prorenin receptor deficiency alters renal medullary endothelin-1 and endothelin receptor expression

The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption. It is unknown if the CD ET and renin/PRR systems interact, hence we examined the effects of deleting CD renin or nephron PRR on CD ET system components. PRR knockout (KO) mice were polyuric and had markedly increased urinary ET-1 and inner …

Antibodies targeting human endothelin-1 receptors reveal different conformational states i…
Decreased hemojuvelin protein levels in mask mice lacking matriptase-2-dependent proteolyt…
Positive allosteric modulator of mGluR4 PHCCC exhibits proconvulsant action in three model…
IB-MECA, an adenosine A3 receptor agonist, does not influence survival of lethally γ-irrad…